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[1] Diljeet Gill, Aled Parry, F¨¢tima Santos, Hanneke Okkenhaug, Christopher D Todd, Irene Hernando-Herraez, Thomas M Stubbs, In¨ºs Milagre, Wolf Reik (2022) Multi-omic rejuvenation of human cells by maturation phase transient reprogramming eLife 11:e71624[2] Cho S, Lee DH, Won CH, Kim SM, Lee S, Lee MJ, Chung JH. Differential effects of low-dose and high-dose beta-carotene supplementation on the signs of photoaging and type I procollagen gene expression in human skin in vivo. Dermatology. 2010;221(2):160-71. doi: 10.1159/000305548. Epub 2010 Jun 2. PMID: 20516658.[3] Joe MJ, Kim SN, Choi HY, Shin WS, Park GM, Kang DW, Kim YK. The inhibitory effects of eckol and dieckol from Ecklonia stolonifera on the expression of matrix metalloproteinase-1 in human dermal fibroblasts. Biol Pharm Bull. 2006 Aug;29(8):1735-9. doi: 10.1248/bpb.29.1735. PMID: 16880634.[4] Oh SJ, Jung SP, Han J, Kim S, Kim JS, Nam SJ, Lee JE, Kim JH. Silibinin inhibits TPA-induced cell migration and MMP-9 expression in thyroid and breast cancer cells. Oncol Rep. 2013 Apr;29(4):1343-8. doi: 10.3892/or.2013.2252. Epub 2013 Jan 24. PMID: 23353996.[5] Jackson JK, Zhao J, Wong W, Burt HM. The inhibition of collagenase induced degradation of collagen by the galloyl-containing polyphenols tannic acid, epigallocatechin gallate and epicatechin gallate. J Mater Sci Mater Med. 2010 May;21(5):1435-43. doi: 10.1007/s10856-010-4019-3. Epub 2010 Feb 17. PMID: 20162329.[6] Nusgens BV, Humbert P, Rougier A, Colige AC, Haftek M, Lambert CA, Richard A, Creidi P, Lapi¨¨re CM. Topically applied vitamin C enhances the mRNA level of collagens I and III, their processing enzymes and tissue inhibitor of matrix metalloproteinase 1 in the human dermis. J Invest Dermatol. 2001 Jun;116(6):853-9. doi: 10.1046/j.0022-202x.2001.01362.x. PMID: 11407971.[7] L¨®pez-Ot¨ªn C, Blasco MA, Partridge L, Serrano M, Kroemer G. Hallmarks of aging: An expanding universe. Cell. 2023 Jan 19;186(2):243-278. doi: 10.1016/j.cell.2022.11.001. Epub 2023 Jan 3. PMID: 36599349.[8] Haynes, P.R., Pyfrom, E.S., Li, Y. et al. A neuron¨Cglia lipid metabolic cycle couples daily sleep to mitochondrial homeostasis. Nat Neurosci 27, 666¨C678 (2024). https://doi.org/10.1038/s41593-023-01568-1[9] Samra T, Gomez-Gomez T, Linowiecka K, Akhundlu A, Lopez de Mendoza G, Gompels M, Lee WW, Gherardini J, Ch¨¦ret J, Paus R. Melatonin Exerts Prominent, Differential Epidermal and Dermal Anti-Aging Properties in Aged Human Eyelid Skin Ex Vivo. Int J Mol Sci. 2023 Nov 4;24(21):15963. doi: 10.3390/ijms242115963. PMID: 37958946; PMCID: PMC10647640.[10] Paluch AE, Boyer WR, Franklin BA, Laddu D, Lobelo F, Lee DC, McDermott MM, Swift DL, Webel AR, Lane A; on behalf the American Heart Association Council on Lifestyle and Cardiometabolic Health; Council on Arteriosclerosis, Thrombosis and Vascular Biology; Council on Clinical Cardiology; Council on Cardiovascular and Stroke Nursing; Council on Epidemiology and Prevention; and Council on Peripheral Vascular Disease. Resistance Exercise Training in Individuals With and Without Cardiovascular Disease: 2023 Update: A Scientific Statement From the American Heart Association. Circulation. 2024 Jan 16;149(3):e217-e231. doi: 10.1161/CIR.0000000000001189. Epub 2023 Dec 7. PMID: 38059362; PMCID: PMC11209834.